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Mechanism of Action: Vitamin B12 Injection (cyanocobalamin) is a synthetic form of vitamin B12 that increases B12 levels in the body

Radioligand and fluorescent binding assays, competition binding, recombinant receptor-expressing cell lines, functional readouts through a defined coupling pathway, and antagonist controls demonstrating that an effect is receptor-mediated

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Dev Biol 296(1):177189 Kalin RE et al (2007) Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis

Population Limitations: As noted previously, the trials did not include elderly individuals, pregnant women, children, or those with certain medical conditions