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Despite initially promising results, SAR425899 has been discontinued after phase 2 trials showed treatment related gastrointestinal disorders (NCT03437720)
Although NNT is a useful tool to translate treatment efficacy into clinical practice, its derivation requires care
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Adipose vs Other NNMT Research Contexts While adipose is the most-developed NNMT-inhibition research application, NNMT biology has been studied in other contexts too: 5-Amino-1MQ as a tool compound has utility across these contexts, but adipose research is currently the deepest and most-established application area
