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There is an urgent need for rigorously designed, large-scale, randomized, placebo-controlled trials that evaluate diverse probiotic formulations within well-defined patient cohorts to generate definitive and reproducible outcomes (280, 453)

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Pardo G, Bar-Or A, Montalban X, et al

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Still, they point out, there are serious questions about the pros and cons of any therapy that produces sustained elevations of growth hormones, with evidence that it could shorten lifespan