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Because medications have highlighted just how hard it is to maintain weight loss when treatment depends on a drug you may need forever

GLP-1 medications usually have a mild to moderate risk of developing side effects

A study presented on June 14 at ENDO 2026, the Endocrine Societys annual meeting in Chicago, had researchers use data from the National Institutes of Healths All of Us Research Program, which links participants electronic health records with their Fitbit activity data

Improved energy levels: By increasing dopamine and norepinephrine levels, bupropion increases energy and motivation, which may stimulate patients to be more physically acti Increased metabolism: Some evidence indicates that bupropion may be able to increase metabolism by a small amount, although the data around this is unclear

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The recent FDA approval of an oral version of semaglutide specifically for weight loss (distinct from Rybelsus , which is used for diabetes) represents a major leap in patient convenience