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Native amylin isn't very useful for therapy because it breaks down quickly and tends to stick together
For mild nausea, smaller meals and stopping before uncomfortable fullness may be easier to tolerate than large meals
the lipidated GLP-1 molecules are bound to albumin, which is too large to be renally filtered, and are thus shielded from plasma proteases
MK-677 presents unique challenges since it's technically not a peptide
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