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The addition of GIP receptor agonism appears to produce stronger effects on triglycerides and HDL in particular

Most recently, data presented at the Heart Rhythm 2026 conference, analysing over 13,000 patients, found that GLP-1 receptor agonists were associated with a reduced risk of atrial fibrillation, and that this appeared to be independent of the medicines' effects on weight

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The American journal of emergency medicine

[7] A boxed warning in the US prescribing information cautions that medullary thyroid cancers have been observed in rats treated with liraglutide, but it is "unknown whether liraglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans, as relevance to humans of such tumors in rodents has not been determined." [7] Thyroid cancer [edit] At exposures eight times greater than those used in humans, liraglutide caused a statistically significant increase in thyroid tumors in rats

ScienceDirect, Enas, Enas A., et al