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Overexpression of IRP2 or MPP + treatment significantly enhances the binding of IRP2 to p53 in PC-12 cells, upregulates p53 levels, downregulates SLC7A11 expression, and increases arachidonate 12-Lipoxygenase (ALOX12) expression, thereby promoting ferroptosis and amino acid antioxidant system disruptions, elevating MDA levels, and inducing PC-12 cell damage

Characteristic appearance: Products containing GHK-Cu display a characteristic blue color , due to the copper ion

pH value and viscosity adjustment pH value adjustment: The pH value of the cream needs to be adjusted to an appropriate range (usually 5.5-7.0) to conform to the physiological environment of the skin and reduce irritation

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Observed effects in human trials Reported adverse events across the IV and oral trials included headache, fatigue, dizziness, nasopharyngitis, diarrhea, flatulence, increased appetite, nausea, and back pain

PMID: 21404916