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A 2025 systematic review found no clinical safety data and only one clinical study, so animal findings do not establish human efficacy
doi:10.1016/j.phrs.2016.11.018 Aviram M, Dornfeld L, Rosenblat M, et al
Reconstitution: Reconstitute using sterile bacteriostatic water or a buffer suitable for your experimental protocol
Some healthcare professionals have hypothesised that immune system changes following correction of severe B12 deficiency might temporarily influence pre-existing inflammatory conditions, though this remains largely theoretical and lacks robust evidence in clinical literature
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