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Appetite and weight trends can continue shifting for longer without other lifestyle support in place

Bottom line: Combining naltrexone and semaglutide may provide a synergistic effect that helps reduce food noise and enhance weight loss, but it must be initiated and monitored by a healthcare provider to ensure safety

Larger areas include the love handles and flanks, the lower and upper abdomen, the full abdomen as a combined area, the inner and outer thighs, the bingo-wing area at the back of the upper arms, and the bra-strap fat at the back

Nature , 593 (7860), 586590

The GLP-1 component also slows gastric emptying, especially early in treatment, meaning food remains in the stomach longer, which prolongs the sensation of fullness following meals

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