Modern lifestyle factors high-sugar, high-fat diets, sleep deprivation, and lack of physical activityfurther slow metabolism, making fat even harder to burn
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Coord Chem Rev, 2022, 451: 214268 Abbas MA, Kamat PV, Bang JH
Results Combination treatment with metformin and liraglutide is more effective than single treatment to protect against palmitic acid (PA)-induced endothelial dysfunction In cultured human umbilical vein endothelial cells (HUVECs), PA induced endothelial dysfunction, characterized by increased reactive oxygen species (ROS) production, decreased NO level and reduced intracellular phosphorylated endothelial NO synthase (p-eNOS) protein level, in a concentration-dependent manner (Fig