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This has been evaluated in the STEP-HFpEF (people with obesity and HFpEF without diabetes) and STEP-HFpEF DM (people with obesity and HFpEF with T2D) trials 44

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Indeed, the increased thrombotic risk caused by hyperhomocysteinemia, recently reviewed by D'Angelo and Selhub (1997), seems to be independent of the conventional risk factors including protein C, protein S, and antithrombin III deficiencies

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AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both