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Role of glucagon-like peptide (GLP-1) on vessel wall integrity The incretin hormone glucagon-like peptide-1 (GLP-1) is produced and secreted in the intestine upon food intake

GLP-1 with its unique mechanism of action

Severe insulin deficiency represents a significant limitationpatients with longstanding type 2 diabetes who have substantial beta-cell dysfunction may not respond adequately to GLP-1 receptor agonists alone, as these medications work by enhancing glucose-dependent insulin secretion

Many patients find their tolerance is dramatically lower than before, making even one drink unpleasant

Yeast infections are not listed as a recognised adverse effect in the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), nor in the European Medicines Agency's European Public Assessment Report (EPAR) for Wegovy

Once denatured, the peptide cannot refold correctly and loses its biological activity