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However, these findings remain preliminary, inconsistent across studies, and have not been robustly demonstrated in well-designed human clinical trials

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Third, although existing studies consistently demonstrate beneficial effects on hepatic steatosis and inflammation, the lack of head-to-head mechanistic and biomarker-based comparisons restricts the ability to distinguish between different GLP-1RAs or combination therapies in terms of their molecular pathways, immunemetabolic regulatory efficiency, and predictive biomarkers of therapeutic response

Emerging evidence suggests a potential association of altered levels of acylcarnitines (ACs), which are involved in mitochondrial fatty acids -oxidation, with insulin resistance, cardiovascular and neurodegenerative diseases [6,7,8,9]

& Gangwisch, J