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This metal-binding arrangement influences the physicochemical properties of the complex and has made GHK-Cu a widely studied model system for investigating copper coordination chemistry, ligand-metal interactions, metallopeptide stability, and copper-dependent signaling mechanisms

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In laboratory settings, GHK-Cu has been studied across a broad range of biological pathways

Finally, the cladogram (in addition to Supplementary Table S1) clearly illustrated that the unclassified genera fell within multiple orders/families