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The foundational epitalon study was published in 2003 by Khavinson and colleagues in the Bulletin of Experimental Biology and Medicine
The role of mitochondrial ROS in the aging brain
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doi:10.1056/NEJMoa2308836 Groti Antonic K
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This complementary mechanism preserves natural feedback loops while significantly amplifying growth hormone secretion, distinguishing it from continuous, non-pulsatile stimulation approaches that may lead to receptor desensitization
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