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This not only reduces the drug's effectiveness but can also create byproducts that may be unsafe
In dendrites of cortical pyramidal neurons lacking a novel MAM protein PDZ domain-containing protein 8, a significant fraction of Ca 2+ released from the ER during synaptic stimulation accumulates in the cytosol and elevates the local dendritic Ca 2+ levels
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This unexpected side effect has left many baffled and seeking answers
It starts with a lower dose that gradually increases over weeks, allowing your body to adjust and reducing potential side effects
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