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Lung Cancer 18:141, 1997
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Mechanism of Action Binds the IGF-1 receptor (IGF-1R) with reduced affinity for IGF-binding proteins, leading to prolonged activation of the PI3K/Akt and MAPK/ERK pathways that promote cell proliferation, differentiation, and inhibition of apoptosis
Therefore, the formation of IBs can pose an important obstacle during the production of recombinant proteins
R.AbbasiF.Abd El-HackM
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