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4.1 Systemic mediators of young blood action 4.1.1 Pigment epithelium-derived factor Among the serine protease inhibitor superfamily, PEDF has attracted attention as a 50-kDa secreted glycoprotein that exerts different physiological activities in various tissues, especially reducing myocardial fibrosis in HF while promoting cardiomyocyte apoptosis, thereby accelerating the progression of HF (6567)

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Unlike certain other peptides, it has minimal impact on other pituitary hormones, which can aid in reducing side effect risk

Thus, the Yc2 subunit is thought to confer protection against AFB 1 , and its induction by EQ is likely to be one of the key mechanisms for the protective action of this anti-carcinogen [56]