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474 Following PHx, the levels of PGs, notably PGE2 and PGF2, are elevated, primarily due to increased synthesis from KCs and hepatocytes

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Timeline: when patients notice changes The first changes most patients report are sleep-related, typically improved sleep depth and morning energy levels, appearing within weeks two to three of the first cycle

Momtazi-Borojeni, A

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ameliorates diet-induced body weight gain and fat accumulation and decreases the levels of serum metabolic biomarkers, such as blood glucose, insulin, and triglycerides 19,20,21,22