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Actionable Next Steps for Researchers: Prioritize Monotherapy Research: Continue to focus on understanding the individual properties and safety profiles of MOTS-c and Retatrutide through well-designed preclinical and clinical studies

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The newly approved oral GLP-1 orforglipron (Foundayo) is a distinct non-peptide small molecule with its own independent patent timeline

In contrast, the potency at human GLP-1R of the exendin-4 disulphide stabilised fusion Ab#2_DSB#1 was better than the glycosylated variant Ab#2_GLP1 W25N/V27S although reduced compared to the non-modified exendin-4 antibody fusion (5.3 nM and to 110 pM, respectively)

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That being said, I dont know, anybody have any tales, any anecdotal, any thoughts, or just even where they want to see this go