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Additionally, as it is a hormone-responsive tissue, it is susceptible to the changing hormonal milieu that is part and parcel of reproductive aging

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For example, studies of healthy females found that the low level of serum folate in 677TT genotype is associated with an increase in homocysteine concentration and DNA hypomethylation 91,92 , which reveals the association between MTHFR C677T polymorphisms and nutrient status

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