10.1016/j.ijpharm.2017.07.031 3 BaeJ.LeeD.KimY
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By supplying folate that is already fully methylated, the supplement entirely bypasses the MTHFR enzymatic bottleneck
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While general nausea and vomiting were listed as common side effects, the drug labels did not initially mention the potential for severe, life-altering gastroparesis or other serious complications