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423 These findings further confirmed the central role of the CNS in regulating the anti-inflammatory effects of GLP-1RAs, highlighting the potential application of GLP-1RAs in anti-inflammatory treatment

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Possible significance and implications for novel mediator[J]

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Tirzepatide with niacinamide adds a B3 vitamin component that some researchers believe supports metabolic function during weight loss

While cagrilintide activates amylin receptors to reduce appetite and slow gastric emptying, semaglutide stimulates GLP-1 receptors to enhance insulin secretion, suppress glucagon, and promote satiety through distinct neural pathways