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Courcoulas AP, King WC, Belle SH, Berk P, Flum DR, Garcia L, et al

Recognizing Demographical Limitations : The authors explicitly note that because this mechanistic trial was executed solely in male mouse models, future trials must include female subjects to verify if the same microbiome-endocannabinoid pathway regulates mood across both sexes

Nutrient Deficiencies Long-term metformin use can reduce vitamin B12 levels, leading to fatigue

Clarke R, Harrison G, Richards S

This study demonstrated that short-term treatment with ARO-HSD reduces hepatic expression of HSD1713 mRNA and protein, which is accompanied by reductions in ALT