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Administration of GN to HFD-induced obese Drosophila melanogaster resulted in weight loss, induction of specific upregulation of lipid storage droplets (Lsd)-2 and hormone sensitive lipase (Hsl), and downregulation of heat shock protein (Hsp90) family members (dGRP94), a key regulator of ERS response

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The other is to actively utilize the hypoxic microenvironment to design prodrugs that selectively intensify local oxidative pressure [487]

Refreshingly low pressure

HDI, highest density interval

These sites are usually responsible for localized toxicity reactions