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CHAC1-mediated GSH degradation reduces S-glutathionylation of ARF6 at cysteine 90, thereby inactivating ARF6 and enhancing ferroptotic cell death ( Similarly, CHAC1 is upregulated in various kidney disease models (Ying et al., 2025)
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Marioni RE, Belsky DW, Deary IJ, Wagner W
10.1186/s40168-016-0178-x Microbiome
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