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A Phase I safety study and a Phase II ulcerative colitis trial of the BPC-157 formulation PL 14736 were conducted by the Croatian pharmaceutical company Pliva, but full peer-reviewed Phase II efficacy results have not been published
The origin is clinically significant: the gastric lining regenerates continuously despite exposure to acid and mechanical stress, and the peptide responsible for that regeneration turned out to be stable enough to isolate and study
PMID: 37513963
This stable gastric penta-decapeptide was used also to provide new insights in treatment of colitis and ischemia and reperfusion in rats, where it was able to quickly restore blood supply to the ischemically injured areas and rapidly activated the growth rate of collateral blood vessels involved the NO system
Primarily it plays a role in purine and pyrimidine synthesis, transfer of methyl groups, and protein formation from amino acids