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However, the reduction was less than what has been reported with semaglutide in T2D 25 , even in those with similar baseline HbA1c
All of these effects, layered on top of tirzepatide gastrointestinal changes, can amplify nausea, acid reflux, and diarrhea in sensitive individuals
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Supporting strategies: Strict sleep hygiene optimizing whatever sleep occurs
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The biggest trial, STEP-1, included over 1900 overweight and obese individuals without T2D, with two-thirds of these volunteers administered 2.4mg/weekly semaglutide
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