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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome

Participants with diabetes or active cardiovascular disease were excluded, as were those pregnant or with uncontrolled comorbidities

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These and other modifications presumably prevent an efficient interaction with GSH as reflected by the absent GSH-dependent reduction of oxidized roGFP2 in the presence of AtGrxS15

R., Bonomini, M

4,9 References Celletti, F., Farrar, J., & De Regil, L