However, careful monitoring and ongoing research are necessary to fully understand its implications

16 Therefore, using a supplemental source of glutathione in addition to regular food sources is a great way to replenish its body stores and compensate age-related depletion.* Glutathione can also have other health-supporting benefits, notably on skin.* 17 Indeed, in a randomized, double-blind, placebo-controlled study healthy women receiving 250 mg/d glutathione or placebo for 12 weeks experienced significantly better skin appearance (melanin index, wrinkle formation as measured by Visioscan) in the glutathione group than in the placebo.* 17 Alpha-lipoic acid (5-(1,2-dithiolan3-yl) pentanoic acid) is another compound involved in the regulation of oxidative stress at the cellular level.* 18 It is found naturally in mitochondria where it acts as the coenzyme for pyruvate dehydrogenase and -ketoglutarate dehydrogenase.* It can also help regenerate glutathione and vitamins C and E.* 19 Pre-clinical animal studies suggest that alpha-lipoic acid supplementation may help to reverse age-associated decline in mitochondrial enzymes and may lower the increased risk of oxidative damage that occurs during the aging process.* Other animal studies have found that alpha-lipoic acid protects the heart mitochondria against the effects of aging.* These animal studies suggest that alpha-lipoic acid supplementation may support healthy aging.* 19 Humans can synthesize alpha-lipoic acid from fatty acids and cysteine, but only in very small amounts

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