There are no reported risks associated with large doses of B12, since the vitamin is water soluble and excess amounts are flushed out of the system
Seek medical advice if you experience: New or worsening vision problems Severe or progressive weakness Loss of coordination or balance Confusion or cognitive changes Seizures These symptoms could indicate underlying conditions requiring investigation
Romani M et al
For randomised clinical trials, the Jadad scale ( To complement the Jadad score, the Cochrane Risk of Bias Tool (RoB 2) (Sterne et al., 2019) was also used for RCTs to provide a domain-based qualitative evaluation, assessing risks related to selection, performance, detection, attrition, and reporting
Patients considering B12 injections should consult their GP for proper assessment and, if indicated, receive treatment through NHS services where safety standards and clinical governance are maintained
The small molecular size makes it favorable for lab use
