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The most promising compounds, 39 and 40 (Figure 6), showed an IC 50 of 2.80 nM against DPP-4 catalytic activity, with 20 - 40-fold selectivity over the DPP-8 and DPP-9 isozymes

Some users experience headaches, appetite loss, or odd color changes in the skin

The trade-off is dramatically reduced efficacy

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However, this increase in metabolic activity is also associated with elevated ROS, which are known modulators of the functions of immune cells 32,41,43,44,103

Leuk Res 1986