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Some studies suggest improvements in structural preservation and functional outcomes, though the mechanisms remain under investigation

Deficiency is common at any age and is largely unrecognised

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This structural difference affects stability, bioavailability, and conversion requirements in the body

We also briefly discuss the therapeutic opportunities of FcRn-targeting beyond autoimmunity

These links reflect shared immunogenetic factors, including IL-18, IFN-, CTLA-4, HLA-DQ8, HLA-DQ2, HLA-B8, and HLA-DR3, many of which are integral to antigen presentation within the major histocompatibility complex (MHC)