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Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers (24, 25)
In aged monkeys, pineal peptide preparations were similarly associated with changes in nocturnal melatonin release patterns and circadian amplitude measurements (7)
Deficiency is particularly common in elderly people because the ability to absorb vitamin B12 can decrease with age