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However, the successful clinical translation of nanomedicine is challenging primarily due to safety concerns [446]

Side Effects and Safety Gastrointestinal, heart-rate, and stomach-emptying effects are coupled to dose and titration speed

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Hydroquinone is applied topically at 24% concentration, and 3545% of the applied dose penetrates the stratum corneum within 6 hours, with peak dermal concentration occurring at 812 hours post-application

Abundant foamy macrophages interspersed with lymphocytes were seen in all these granulomas

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