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5-Amino-1MQ is a substrate-mimetic inhibitor occupying the nicotinamide binding site, with a reported IC of 1.2 0.1 M (Neelakantan et al., J Med Chem, 2017)
Following incubation, the absorbance at 450 nm was measured for each well using a microplate reader
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Current 5-Amino-1MQ research focuses on its interaction with nicotinamide N-methyltransferase (NNMT)-associated biochemical pathways, NAD+-related signaling, and cellular energy metabolism studied in controlled laboratory and in vitro environments
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