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Contraindications are also common across the class, including a personal or family history of medullary thyroid cancer, multiple endocrine neoplasia type 2, and severe renal or hepatic impairment

We measured the changes from baseline in outcomes of HbA 1c concentrations, fasting blood glucose concentrations, body weight, body mass index, waist circumference, and serum lipid parameters, eg, high density lipoprotein, low density lipoprotein, total cholesterol, and triglyceride levels

Importantly, while weight loss was observed in these trials, the degree of improvement in cardiac outcomes were often disproportionate to the weight reduction alone, suggesting at weight loss-independent mechanisms 30,31,44

GLP-1RAs include liraglutide (Saxenda) and semaglutide (Wegovy)

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Here, we report the effects of two clinically approved glutamate modulators: acetyl-L-carnitine (ALCAR) and S, R()ketamine (KET)