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Journal of Cellular Biochemistry Supplement (1996) 24:32-91 (HHS Ref
The PS framework has become more known in drug development since its inclusion as one of the five strategies for handling intercurrent events in the estimand framework (ICH E9(R1) guideline 2020) and the availability of programming macros
INS-1 cells were grown in RPMI containing 10% (vol/vol) fetal calf serum, 10 mM HEPES, 2 mM L-glutamine, 1 mM sodium pyruvate, and 0.05 mM 2-mercaptoethanol at 37 C with 5% CO 2
The cost for lab work may vary, depending on how routine or specialized the tests are
Weeks 13 onward: 12mg once weekly (maximum studied dose)
FUNDING This study was supported by Chang Gung Memorial Hospital (CMRPG3K0481 and CMRPG3L0251)
