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Patients with pernicious anemia have an irreversible cause of deficiency, so its important to ensure other factors do not contribute to further deficiency progression

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& Zhou, C

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Meyer, A

These results reveal the dynamic interplay between the structural states of the CRL4 DET1-COP1 E3 ligase complex and its substrate specific activation mechanism, offering mechanistic insights into ubiquitination regulation and a basis for future studies on E3 ligase dynamics