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Between 2017 and 2022, GLP-1 medication use among people with diabetes increased by 230%, rising from approximately 1.5 million to 5.1 million adults
Both medications reduce appetite through different mechanisms, and combining them could increase side effects without proportionally better results
The subsequent phase 3 trial of tirzepatide demonstrated more effective reductions in the glycated hemoglobin levels and body weight, along with greater overall improvements in the lipid profile compared to semaglutide in patients with T2DM, elevating incretin therapeutic agents to a new level (112)
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True, R
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