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On the other hand, SGLT-2is causes early benefit on heart failure than GLP-1RAs, shows improved hemodynamics and sympathetic inhibition, and is frequently applied for treatment of T2D patients with higher risks of progression to severe heart failure

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Following 24 h of treatment, 20 L of MTT reagent (5 mg/mL in PBS) was added to each well and incubated for an additional 4 h at 37 C

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Unexpectedly, patients began shedding weight while using them, sparking interest in their potential for weight loss