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Semaglutide (injectable or oral Wegovy): 10-17% | Phentermine/Topiramate: 8-10% | Bupropion/Naltrexone: 4-8% | Metformin: 2-5% | Retatrutide (not yet approved): ~28% in Phase 3 trials

4 Preclinical evidence: a foundation of neuroprotection The considerable interest in semaglutide as a neurotherapeutic agent is derived from a robust body of preclinical evidence

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For patients managing type 2 diabetes, both medications significantly improve blood sugar control by lowering A1C levels