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4 In blood diseases like leukemia, polycythemia vera and hypereosinophylic syndrome, the cause is often an enhanced production of the transport protein haptocorrin, to which most of the circulating B12 in blood is bound

The best way to get enough vitamin B12 is through a healthy diet whenever possible, such as from consuming grass-fed beef, poultry or wild-caught fish

Individuals with known hypersensitivity to ascorbic acid, those with a history of oxalate kidney stones, G6PD deficiency, iron overload disorders, or severe renal impairment should avoid this product

UV light may trigger certain proteins in the skin, setting off a chain of events that eventually stimulate melanin production, leading to the spotted, darkly pigmented skin seen in patients with Riehl melanosis

Lopez-D'alessandro E., Escovich L

Consider whether you can commit to permanent lifestyle changes, long term medication use and regular monitoring