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If the FDA finalizes its April 30, 2026 proposal to exclude semaglutide and tirzepatide from the 503B Bulks List, large-scale 503B compounding of those medications would no longer be legally permissible

HPB 13 , 5158 (2011)

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The ADP-ribosylation renders RNA resistant to phosphatase, which might protect the RNA from the nuclease attack