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J Nephropathol

A phenotype beneficial in one disease stage or anatomical region may prove deleterious in another

Note that strong chelators, phosphate-rich buffers and reducing agents in an experimental medium will compete for the copper centre and alter the species actually present

piezogenic papules) Edema in the legs in the absence of cardiac failure Mild proximal and distal muscle weakness Axonal polyneuropathy Atrophy of muscles in hands and feet Acrogeric hands, mallet finger(s), clinodactyly, brachydactyly Vaginal/uterus/rectal prolapse Dermatosparaxis EDS (dEDS) If a person meets the diagnostic criteria for dEDS, genetic testing should be done to confirm the diagnosis

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