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2018;172(e421):40922
References: NICE Technology Appraisal: Tirzepatide for managing overweight and obesity NICE NG28: Type 2 diabetes in adults: management MHRA/EMC Summary of Product Characteristics: Mounjaro (tirzepatide) Faculty of Sexual and Reproductive Healthcare (FSRH) CEU statement on GLP-1 receptor agonists and oral contraception No, Mounjaro is definitively not a steroid
Animal studies suggest GLP-1 signaling in the brain may help recalibrate sleep-wake cycles entirely independent of body weight changes, though these findings have not yet been replicated in humans (ref)
Use of metformin in pediatric patients
5-Fluorouracil induced hyperammonemic encephalophathy: etiopathologic correlation
Hence, we strongly encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with uncontrolled metabolic risks, i.e., especially those who need to lose weight and/or control high blood pressure
