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Fruetel JA et al
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(2025) Nat Commun 16 : 3389-3389 PubMed: 40204768 Search on PubMedSearch on PubMed Central DOI: Primary Citation Related Structures: 9BLB, 9BLC, 9BLW, 9BP3, 9BQ3, 9BTW, 9BUB, 9BUC, 9BUD, 9BUE PubMed Abstract: Obesity is a major and increasingly prevalent chronic metabolic disease with numerous comorbidities
PMC What to expect at 8 weeks: More noticeable brightening of dull or uneven areas Reduction in pigment spots, sun spots, or mild freckles Skin tone looks more even, with softer transitions between light/dark zones Better radiance, not just lightness Complementary skincare results (like from sunscreen, vitamins) become more evident However, results still differ widely between people
retatrutide is an incretin-based triple agonist adding GIP, GLP-1, and glucagon activity
Once it's in a liquid state, the peptide is much more susceptible to degradation
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