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Patients with MetSR demonstrated statistically significant improvement in depressive symptoms (DCD: SMD = 0.72, 95% CI: 1.41 to 0.03), while non-MetSR conditions showed no significant treatment effect (SMD = 0.57, 95% CI: 1.33 to 0.18)

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For a complete washout of Tirzepatide (meaning negligible residual activity), researchers might consider a gap of 2 to 4 weeks (or 2-4 half-lives) after the last high dose of Tirzepatide