Common adverse effects are predominantly gastrointestinal and typically emerge during dose escalation: Nausea (affecting 2050% of users initially) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (therapeutic effect but may be excessive) Fatigue and headache Injection site reactions (redness, swelling or itching) These effects usually diminish over several weeks as the body adjusts
15,26 Importantly, these findings should be interpreted in the context of the observational study design
Obesity is one of the strongest risk factors and predisposition for type 2 diabetes (169, 171)
Crohn's Disease and Ozempic: Safety, Risks and Alternatives Ozempic (semaglutide) is a GLP-1 receptor agonist licensed in the UK for type 2 diabetes management, but its use in patients with Crohn's disease raises important safety considerations
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Incorporate Exercise: Aim for a mix of cardiovascular exercises (walking, swimming) and strength training to maintain bone density and muscle mass