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doi: 120
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Another study found TMAO downregulates Piezo1, activating NOX4/ROS oxidative stress, causing abnormal calcium handling and fibrosis, constituting the molecular network of TMAO-induced cardiac fibrosis ( The above quadruple network links cardiac fibroblast proliferation, ER stress response, inflammatory signals and epigenetics, which together constitute the pathological basis of TMAO-induced fibrosis
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Pregnancy or breastfeeding: The safety of GHK-Cu during these periods has not been definitively established, so it's best to avoid use
